Membrane Preparations

Purified GPCR and Ion Channel Membrane Preps for Binding and Functional Analysis

Membrane preps are useful for studying the role of membrane proteins in diseases and their response to therapeutics. Eurofins DiscoverX® GPCR and ion channel membrane preps are derived from stable cell lines expressing optimal protein levels to be assayed. They are designed for determining membrane protein binding affinities through saturation and competitive radioligand binding analysis and can be used for rank ordering and screening of small molecule or protein therapeutics. For GPCRs, these membrane preps can also be used to perform GTPγS functional studies to evaluate GPCR activity in response to the addition of a ligand or therapeutic.

Utilize Eurofins DiscoverX’s purified membrane preps for highly sensitive and reproducible results you can rely on.

Product Highlights
  • Robust Performance – Large signal-to-background ratios with specific and high ligand binding capacity
  • Reproducible – Produced from stable clonal cell lines for superior protein expression and lot-to-lot consistency
  • Simple – Removes the need for cell culture
  • Versatile Use – Applicable for saturation and competitive radioligand binding, therapeutic small molecule and antibody screening and ranking, and GTPγS functional studies
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Products

  • ChemiSCREEN™ GPCRs Membrane Preps – Purified cell membrane preps expressing high levels of specific target GPCR proteins are applicable for determining GPCR activity via GTPγS assay and binding affinities via saturation and competitive binding assays.
  • PrecisION™ Ion Channel Membrane Prep – Purified cell membrane prep expressing high levels of ion channel targets for the determination of binding affinities via saturation and competitive binding assays