Biological Information | |
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Background Information: | The mammalian Abelson (Abl) family of non-receptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression.
GenBank XM_136360. The recombinant protein also contains 2 residues which are in conflict with GenBank XM_136360. These are M982V, reported in GenBank NM_005158, NM_007314, M35296, and an A inserted at position 562, reported in GenBank U40827. The residue coordinates in the native sequence have been given. |
Target Class: | Kinase |
Accession Number: | NM_005158.2; NM_007314.1 |
Target Name: | Arg |
Target Aliases: | ABL proto-oncogene 2, non-receptor tyrosine kinase, ABL2, Abelson-related, ABLL, ARG |
Target Species: | Mouse |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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