Biological Information | |
---|---|
Background Information: | Polo-like kinases (PLKs) are a family of serine/threonine kinases related to the polo gene product of Drosophila melanogaster, originally identified from a mitotic mutant that displayed abnormal spindle poles. PLKs play essential roles in several stages of mitosis and cytokinesis with a dynamic pattern of localization to centrosomes, kinetochores and central spindle structures during the cell cycle. PLK1 has been shown to be overexpressed in many human tumors, such as non-small cell lung cancer, squamous cell carcinomas of the head and neck, melanomas, oropharyngeal carcinomas, and ovarian and endometrial carcinomas.
GenBank NM_005030 |
Target Class: | Kinase |
Accession Number: | NM_005030 |
Target Name: | Plk1 |
Target Aliases: | PLK, PLK1, STPK13 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Datasheets
14-777x Datasheet
View Document