Biological Information | |
---|---|
Background Information: | MAP4K4 is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Target Class: | Kinase |
Family: | Ser/Thr Kinase |
Accession Number: | NM_004834.4 |
Target Name: | MAP4K4 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
MAP4K4, active
N-terminal GST tagged and C-terminal 6His tagged, recombinant, human MAP4K4 amino acids 1-328, expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography.
Datasheets
15-012x Datasheet
View Document