Lck, activated

N-terminal 6His-tagged recombinant, human full length Lck.

Catalog #: 14-842

$399.00$2,989.00


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Biological Information
Background Information:
The Lck proto-oncogene is a member of the Src-related gene family of non-receptor tyrosine kinases. It is uniquely expressed only in T-lymphocytes and NK-cells. The p56lck kinase (LCK) is a 56 KD polypeptide that is associated with a cytoplasmic face of the plasma membrane. It functions as a critical Signaling model in IL-2 signal transduction leading to T-lymphocyte activation. Specifically, it has been shown that a stable complex exists between IL-2 receptors and p56lck and that treatment of T-lymphocytes with IL-2 promotes p56lck kinase activity and rapid phosphorylation of cellular substrates. In addition, p56lck has been found to function as a signal transducer for antigen activated CD4 and CG8 T-cell receptors and plays a role in thymic maturation of certain T-cells. The CD45 antigen, a receptor/protein tyrosine phosphatase of T-cells, also interacts with p56lck. GenBank NM_005356
Target Class:
Kinase
Accession Number:
Refer to CoA for Accession Number
Target Name:
Lck
Target Aliases:
LCK, pp58lck, LSK, p56-LCK, p56lck, YT16
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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Datasheets

14-842x Datasheet

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