Biological Information | |
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Background Information: | Two high affinity VEGF receptors, Flt-1 (VEGFR-1, activated by placental growth factor PlGF) and KDR (Kinase insert domain receptor, Flk-1/VEGFR2, activated by VEGF), have been identified. These receptors can be divided into three structural regions: seven extracellular Ig-like domains that contain the growth factor binding sites, a single polypeptide chain hydrophobic trans-membrane sequence, and intracellular cytoplasmic domains that confer the tyrosine kinase activity required for signal transduction. VEGF-B and VEGF-D homologues bind with high affinity to FLT1 (fms-related tyrosine kinase 1, vascular endothelial growth factor/vascular permeability factor receptor).
GenBank NM_002253 |
Target Class: | Kinase |
Family: | Receptor Typosine Kinase (RTK): Growth Factor Receptor |
Accession Number: | NM_002253.1 |
Target Name: | KDR |
Target Aliases: | KDR, VEGFR-2, VEGFR2, CD309, FLK1, VEGFR |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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