Cdk7/Cyclin H/MAT1 (CAK complex), active

Complex of recombinant, human full length cdk7, containing a C-terminal 6His-tag, recombinant, human full length cyclin H untagged and recombinant, human full length MAT1 containing an N-terminal GST-tag.

Catalog #: 14-476

$399.00$2,989.00


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Biological Information
Background Information:
Cyclin-dependent Kinase 7 (cdk7) is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. GenBank X79193 / GenBank U11791 / GenBank X87843
Target Class:
Kinase
Family:
Serine/Threonine Kinase: CDK7 subfamily
Accession Number:
NM_001799.2
Target Name:
CDK7/cyclinH/MAT1
Target Aliases:
CDK7, p39MO15, CAK, CAK1, MO15, CDKN7, STK1
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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Datasheets

14-476x Datasheet

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