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[User Manual] PathHunter® Signaling Pathway Reporter Assay

[User Manual] PathHunter® Signaling Pathway Reporter Assay
Version:
70-406

File Name/Number:
70-406

Year:
2019

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The PathHunter Signaling Pathway Reporter Assays are stable clonal cell lines used for monitoring the activation of various signaling pathways. Ligands (for example, CD40, IL-6 etc.) bind to distinct receptors and trigger specific signaling pathways. Transcription factors are then activated, followed by their nuclear translocation. Binding of these activated transcription factors to specific promoter elements regulates downstream gene transcription, leading to protein expression.