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Uncover Novel G-Protein or Arrestin-Biased Ligands Using a Suite of GPCR Signaling Cell-Based Assays: A Study of Biased Agonism on Opioid Receptors

Uncover Novel G-Protein or Arrestin-Biased Ligands Using a Suite of GPCR Signaling Cell-Based Assays: A Study of Biased Agonism on Opioid Receptors
Year:
2021

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As more is learned about the intricacies of GPCR signaling, the harder it becomes to accurately describe ligand activity using a single functional readout. This creates the need for a comprehensive suite of natually coupled cell-based assays that allow quantitative examination of multuple signaling pathways in parallel using the same robust, reliable, and high-throughput screening friendly format. Eurofins DiscoverX has developed an industry-leading menu of functional assays designed to detect GPCR signaling through second messenger activation, Arrestin binding, and receptor internalization. Access to the same target in multiple readouts provides a unique opportunity to identify novel biased ligands that selectively target different aspects of GPCR activation in hopes of developing new and improved drugs with greater therapeutic benefit.