PathHunter® Build Your Own β-Arrestin Assays
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β-Arrestins are ubiquitously expressed and function in the activation of GPCRs, desensitization of most 7 transmembrane receptors, and regulation of other signaling molecules such as protein kinases. For GPCRs, ligand-induced β-arrestin recruitment activates signaling cascades independent of G-protein signaling to provide a nonamplified signal which is ideal for antagonist mode screening, ligand pharmacology analysis, and GPCR deorphanization. DiscoverX provides a complete set of tools to create stable β-arrestin cell lines in any cell type and generate your own β-arrestin assay.