Targets by Family


AAK1 ABL1 ABL1(E255K)-phosphorylated ABL1(F317I)-nonphosphorylated ABL1(F317I)-phosphorylated
ABL1(F317L)-nonphosphorylated ABL1(F317L)-phosphorylated ABL1(H396P)-nonphosphorylated ABL1(H396P)-phosphorylated ABL1(M351T)-phosphorylated
ABL1(Q252H)-nonphosphorylated ABL1(Q252H)-phosphorylated ABL1(T315I)-nonphosphorylated ABL1(T315I)-phosphorylated ABL1(Y253F)-phosphorylated
ABL1-nonphosphorylated ABL1-phosphorylated ABL2 ACVR1 ACVR1B
ACVR1B/BMPR2 ACVR1C/ACVR2 ACVR1C/ACVR2B ACVR2/ACVR1 ACVR2A
ACVR2B ACVRL1 ACVRL1/ACVR2 ACVRL1/ACVR2B ACVRL1/BMPR2
ADCK3 ADCK4 ADCYAP1R1 ADORA1 ADORA2A
ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D(82-572)
ADRA2A ADRA2B ADRA2C ADRB1 ADRB2
ADRB2(W158A) ADRB3 AGTR1 AGTRL1 AKT1
AKT2 AKT3 ALK ALK(1151Tins) ALK(C1156Y)
ALK(F1174L) ALK(L1196M) AMPK-alpha1 AMPK-alpha2 ANKK1
AR ARK5 ASK1 ASK2 ATAD2A
ATAD2B ATAD2B AURKA AURKB AURKC
AVPR1A AVPR1B AVPR2 AVPR2(S167T) AXL
BAI1 BAI2 BAI3 BAZ1A BAZ1B
BAZ2A BAZ2A BAZ2B BCL2-BAX BCL2-BIM
BCL2L1-BAX BCL2L1-BIM BCMA BDKRB1 BDKRB2
BIKE BLK BMPR1A BMPR1A/ACVR2 BMPR1A/ACVR2B
BMPR1A/BMPR2 BMPR1B BMPR1B/ACVR2 BMPR1B/ACVR2B BMPR1B/BMPR2
BMPR2 BMX BRAF BRAF(V600E) BRD1
Brd2(1) BRD2(1,2) BRD2(2) BRD3(1) BRD3(1)
BRD3(1,2) BRD3(2) Brd4(1) BRD4(1,2) BRD4(2)
BRD4(full-length,short-iso.) Brd7 BRD8(1) BRD8(2) BRD9
BrdT(1) BRDT(1,2) BRDT(2) BRK BRPF1
BRPF3 BRPF3 BRS3 BRSK1 BRSK2
BRWD3(2) BTK BUB1 C3AR1 C5AR1
C5L2 CALCR CALCRL-RAMP1 CALCRL-RAMP2 CALCRL-RAMP3
CALCR-RAMP2 CALCR-RAMP3 CAMK1 CAMK1B CAMK1D
CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G
CAMK4 CAMKK1 CAMKK2 CASK CASR
CCKAR CCKBR CCR1 CCR10 CCR2
CCR3 CCR4 CCR5 CCR6 CCR7
CCR8 CCR9 CCRL1 CCRL2 CD137
CD33 CD86 CDC25A CDC2L1 CDC2L2
CDC2L5 CDK1 CDK10 CDK11 CDK12
CDK2 CDK20 CDK3 CDK4 CDK4-cyclinD1
CDK4-cyclinD1(F93L) CDK4-cyclinD3 CDK5 CDK6 CDK7
CDK8 CDK9 CDKL1 CDKL2 CDKL3
CDKL5 CECR2 cEDG5 CFTR-ΔF508 cGPR91
CHEK1 CHEK2 CHRM1 CHRM2 CHRM3
CHRM4 CHRM5 cINSRa cINSRb CIT
c-KIT CLK1 CLK2 CLK3 CLK4
c-MET/c-MET CMKLR1 CNR1 CNR2 CREBBP
c-Ret-GFRα1 c-Ret-GFRα2 CRHR1 CRHR2 CRTH2
CSF1R CSF1R/CSF1R CSF1R-autoinhibited CSF2RB/CSF2RA CSF3R-JAK1
CSK CSNK1A1 CSNK1A1L CSNK1D CSNK1E
CSNK1G1 CSNK1G2 CSNK1G3 CSNK2A1 CSNK2A2
CTK CTLA4 CX3CR1 CXCR1 CXCR2
CXCR3 CXCR4 CXCR5 CXCR6 CXCR7
cyno CXCR1 cyno CXCR2 cyno GPR120 cyno MRGPRX2 CYSLTR2
DAPK1 DAPK2 DAPK3 DARC DCAMKL1
DCAMKL2 DCAMKL3 DDR1 DDR2(T654M) DLK
DMPK DMPK2 DRAK1 DRAK2 DRD1
DRD2L DRD2S DRD3 DRD4 DRD5
DYRK1A DYRK1B DYRK2 EBI2 EDG1
EDG2 EDG3 EDG4 EDG5 EDG6
EDG7 EDNRA EDNRB EGFR EGFR(E746-A750del)
EGFR(G719C) EGFR(G719S) EGFR(L747-E749del, A750P) EGFR(L747-S752del, P753S) EGFR(L747-T751del,Sins)
EGFR(L858R) EGFR(L858R,T790M) EGFR(L861Q) EGFR(S752-I759del) EGFR(T790M)
EGFR/EGFR EGFR/ErbB2 EGFR/ErbB3 EIF2AK1 EP300
EP300 EPHA1 EPHA2 EPHA3 EphA4
EphA5 EPHA6 EphA7 EPHA8 EphB1
EphB2 EphB3 EphB4 EPHB6 EpoR/EpoR
EpoR-JAK2 ErbB1 ERBB2 ErbB2/ErbB3 ErbB2/ErbB4
ErbB2-ErbB3 ERBB3 ErbB4 ErbB4/ErbB4 ERK1
ERK1(Q122L) ERK2 ERK3 ERK4 ERK5
ERK8 ERN1 ERRα ERα F2R
F2RL1 F2RL3 FAK FALZ FALZ
FER FES FFAR1 FFAR2 FFAR3
FGFR1 FGFR1-α-Klotho FGFR1-β-Klotho FGFR2 FGFR2(N550K)
FGFR3 FGFR3(G380R)/FGFR3(G380R) FGFR3(G697C) FGFR3(K650E) FGFR3(V555M)
FGFR3/FGFR3 FGFR4 FGFR4 FGFR4-α-Klotho FGFR4-β-Klotho
FGR FLT1 FLT3 FLT3(D835H) FLT3(D835V)
FLT3(D835Y) FLT3(ITD) FLT3(ITD,D835V) FLT3(ITD,F691L) FLT3(K663Q)
FLT3(N841I) FLT3(R834Q) FLT3-autoinhibited FLT4 FOXO3
FPR1 FPR3 FPRL1 FRK FSHR
FXR FYN G9a GABBR1-GABBR2 GAK
GALR1 GALR2 GCGR GCN2(Kin.Dom.2,S808G) GCN5L2
GHRHR GHR-JAK1 GHR-JAK2 GHSR GHSR1b
GIPR GLP GLP1R GLP2R GNRHR
GPBAR1 GPR1 GPR101 GPR103 GPR107
GPR109A GPR109B GPR119 GPR12 GPR120
GPR120S GPR123 GPR132 GPR135 GPR137
GPR139 GPR141 GPR142 GPR143 GPR146
GPR148 GPR149 GPR15 GPR150 GPR151
GPR152 GPR157 GPR161 GPR162 GPR17
GPR171 GPR173 GPR176 GPR18 GPR182
GPR20 GPR22 GPR23 GPR25 GPR26
GPR27 GPR3 GPR30 GPR31 GPR32
GPR35 GPR37 GPR37L1 GPR39 GPR4
GPR45 GPR50 GPR52 GPR55 GPR6
GPR61 GPR65 GPR75 GPR78 GPR79
GPR81 GPR83 GPR84 GPR85 GPR88
GPR92 GPR97 GR GRK1 GRK2
GRK3 GRK4 GRK7 GRM1 GRM2
GRM3 GRM4 GRM5 GRM6 GRPR
GSK3A GSK3B HASPIN HCK HCRTR1
HCRTR2 HIPK1 HIPK2 HIPK3 HIPK4
HPK1 HRH1 HRH2 HRH3 HRH4
HTR1A HTR1B HTR1E HTR1F HTR2A
HTR2B HTR2C HTR2C(VGV) HTR2C(VNV) HTR2C(VSV)
HTR5A HTR6 HTR7A HTR7B HTR7D
HUNK ICK IFNAR1/IFNAR2 IFNGR1/IFNGR2 IFNRL1/IL10RB
IGF1R IKK-alpha IKK-beta IKK-epsilon IL10RA/IL10RB
IL11RA/IL6ST IL12RB1/IL12RB2 IL17RA/IL17RC IL17RD/TNFR2 IL18R1/IL18RAP
IL1R1/IL1RAP IL1RL1/IL1RAP IL20RA/IL10RB IL20RA/IL20RB IL21R/IL2RG
IL22RA1/IL10RB IL23R/IL12RB1 IL27RA/IL6ST IL2RB/IL2RG IL2RB/IL2RG/IL2RA
IL31RA/OSMRb IL3RA/CD131 IL4R/IL13RA1 IL4R/IL2RG IL5RA/CD131
IL6R/IL6ST IL7R/CRLF2 IL7R/IL2RG IL9R/IL2RG INSR
INSRa INSRb INSRR IRAK1 IRAK2
IRAK3 IRAK4 ITK IκB JAK1(JH1domain-catalytic)
JAK1(JH2domain-pseudokinase) JAK2(JH1domain-catalytic) JAK3 JAK3(JH1domain-catalytic) JNK1
JNK2 JNK3 KCNH2(G601S) KDR KDR/KDR
Keap1-NRF2 KISS1R KIT KIT(A829P) KIT(D816H)
KIT(D816V) KIT(L576P) KIT(V559D) KIT(V559D,T670I) KIT(V559D,V654A)
KIT-autoinhibited LATS1 LATS2 LCK LGR4
LGR5 LGR6 LHCGR LIMK1 LIMK2
LKB1 LOK LRRK2 LRRK2(G2019S) LTB4R
LTK LXRα LXRβ LXRβ-NCoR1 LYN
LZK mADCYAP1R1 mADORA2B mADORA3 mADRA1B
mAGTRL1 MAK MAP3K1 MAP3K15 MAP3K2
MAP3K3 MAP3K4 MAP4K2 MAP4K3 MAP4K4
MAP4K5 MAPKAPK2 MAPKAPK5 MARK1 MARK2
MARK3 MARK4 MAST1 mAVPR2 mBRS3
MC1R MC3R MC4R MC4R(T162I) mC5AR1
MC5R mCCKAR mCCR1 mCCR2 mCCR3
mCCR4 mCCR5 mCCR6 mCCR7 mCCR8
mCCR9 MCHR1 MCHR2 MCL1-BIM mCMKLR1
mCNR1 mCNR2 mCRHR1 mCRTH2 mCX3CR1
mCXCR2 mCXCR3 mCXCR4 mCXCR5 mCXCR6
mCXCR7 mDRD5 mEBI2 mEDG1 mEDG3
mEDG5 mEDNRA mEDNRB MEK1 MEK2
MEK3 MEK4 MEK5 MEK6 MELK
MERTK MET MET(M1250T) MET(Y1235D) mF2RL1
mFFAR1 mFPR1 mFPR2 mGALR1 mGALR2
mGCGR mGHSR mGIPR mGLP1R mGLP1R-ADCY2
mGPR1 mGPR120 mGPR84 mHCRTR1 mHTR2A
mHTR2C MINK mINSRa mINSRb MKK7
MKNK1 MKNK2 MLCK MLK1 MLK2
MLK3 MLKL MLKL(full-length) MLL MLNR
mLTB4R mMC3R mMC4R mMC5R mMCHR1
mNPY1R mNPY2R mOPRD1 mOPRK1 mOPRM1
mOXTR mP2RY12 mP2RY6 mPPYR1 mPTAFR
mPTGER4 mPTGIR MR MRCKA MRCKB
MRGPRD MRGPRE MRGPRF MRGPRX1 MRGPRX2
MRGPRX4 mRHO(P23H) mRXFP1 mRXFP3 mRXFP4
mSSTR2 mSSTR5 MST1 MST1R MST2
MST3 MST4 mTAAR1 mTACR1 MTH1
MTNR1A MTNR1B MTOR MUSK mUTR2
mVIPR1 MYLK MYLK2 MYLK4 MYO3A
MYO3B NDR1 NDR2 NEK1 NEK10
NEK11 NEK2 NEK3 NEK4 NEK5
NEK6 NEK7 NEK9 NIK NIM1
NLK NMBR NMU1R NPBWR1 NPBWR2
NPFFR1 NPR1 NPSR1b NPY1R NPY2R
NTSR1 OPN5 OPRD1 OPRK1 OPRL1
OPRM1 OSMR/IL6ST OSR1 OX40 OXER1
OXGR1 OXTR P2RY1 P2RY11 P2RY12
P2RY2 P2RY4 P2RY6 P2RY8 p38-alpha
p38-beta p38-delta p38-gamma P53 PAK1
PAK2 PAK3 PAK4 PAK6 PAK7
PASK PB1(1) PB1(2) PBRM1(2) PBRM1(5)
PCAF PCTK1 PCTK2 PCTK3 PD-1
PDGFRa PDGFRb PD-L1 PD-L1/PD-L1 PD-L2
PDPK1 PFCDPK1(P.falciparum) PFPK5(P.falciparum) PFTAIRE2 PFTK1
PHIP(1) PHIP(2) PHKG1 PHKG2 PI3Kδ
PIK3C2B PIK3C2G PIK3CA PIK3CA(C420R) PIK3CA(E542K)
PIK3CA(E545A) PIK3CA(E545K) PIK3CA(H1047L) PIK3CA(H1047Y) PIK3CA(I800L)
PIK3CA(M1043I) PIK3CA(Q546K) PIK3CB PIK3CD PIK3CG
PIK4CB PIKFYVE PIM1 PIM2 PIM3
PIP5K1A PIP5K1C PIP5K2B PIP5K2C PKAC-alpha
PKAC-alpha(L206R) PKAC-beta PKMYT1 PKN1 PKN2
PKNB(M.tuberculosis) PLK1 PLK2 PLK3 PLK4
PPARα PPARγ PPARδ PPYR1 PRKCBP1
PRKCD PRKCE PRKCH PRKCI PRKCQ
PRKD1 PRKD2 PRKD3 PRKG1 PRKG2
PRKR PRKX PRLHR PRLR-JAK1 PRLR-JAK2
PRMT3 PROKR1 PROKR2 PRP4 PRα
PRβ PTAFR PTGDR PTGER1 PTGER2
PTGER3 PTGER4 PTGFR PTGIR PTHR1
PTHR2 PYK2 QSK RAF1 RANK-IκB
RARα RARβ rCHRM4 rCNR2 rCRTH2
rDRD1 rDRD2L rDRD2S rEDG5 RELA-IκB
RET RET(A883F) RET(M918T) RET(V804E) RET(V804L)
RET(V804M) rFFAR1 rGPR120 rGPR35 rHTR2C
rhTrkA-rhP75 RIOK1 RIOK2 RIOK3 RIPK1
RIPK1 RIPK2 RIPK3 RIPK3 RIPK4
RIPK5 ROCK1 ROCK2 rOPRM1 ROS1
rPROKR1 rPROKR2 RPS6KA4(Kin.Dom.1-N-terminal) RPS6KA4(Kin.Dom.2-C-terminal) RPS6KA5(Kin.Dom.1-N-terminal)
RPS6KA5(Kin.Dom.2-C-terminal) rPTGER4 RSK1(Kin.Dom.1-N-terminal) RSK1(Kin.Dom.2-C-terminal) RSK2(Kin.Dom.1-N-terminal)
RSK2(Kin.Dom.2-C-terminal) RSK3(Kin.Dom.1-N-terminal) RSK3(Kin.Dom.2-C-terminal) RSK4(Kin.Dom.1-N-terminal) RSK4(Kin.Dom.2-C-terminal)
rTAAR1 rTrkA-rP75 rVIPR1 RXFP1 RXFP2
RXFP3 RXFP4 RXRα RXRγ S6K1
SBK1 SCTR sEDG5 SGK SgK110
SGK2 SGK3 Siglec9 SIK SIK1
SIK2 SLK SMARCA2 SMARCA4 SMO(W535L)
SNARK SNRK SP110 SP140 SRC
SREBP2 SRMS SRPK1 SRPK2 SRPK3
SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
STK16 STK33 STK35 STK36 STK39
SYK TAAR1 TAAR5 TACR1 TACR2
TACR3 TAF1(1,2) TAF1(2) TAF1L(1) TAF1L(2)
TAK1 TAOK1 TAOK2 TAOK3 TBK1
TBXA2R TEC TESK1 TGFBR1 TGFBR1/ACVR2
TGFBR1/ACVR2B TGFBR1/TGFBR2 TGFBR1/TGFBR2/ENG TGFBR2 THRα
THRβ TIE1 TIE2 Tie2 TIM3/TIM3
TLK1 TLK2 TNFα TNIK TNK1
TNK2 TNNI3K TORC1 TORC2 TPOR/TPOR
TRHR TRIM24(Bromo.) TRIM24(PHD,Bromo.) TRIM33 TRIM33(PHD,Bromo.)
TrkA TrkA-P75 TrkB TrkB-P75 TrkC
TrkC-P75 TRPM6 TSHR(L) TSSK1B TSSK3
TTK TXK TYK2 TYK2(JH1domain-catalytic) TYK2(JH2domain-pseudokinase)
TYRO3 ULK1 ULK2 ULK3 UTR2
VEGFR2 VIPR1 VIPR2 VISTA/VISTA VPS34
VRK2 WDR9(1) WDR9(2) WEE1 WEE2
WNK1 WNK2 WNK3 WNK4 XBP1
XCR1 YANK1 YANK2 YANK3 YES
YES1 YSK1 YSK4 ZAK ZAP70
β-Catenin