Targets / Signaling Pathways
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Signaling Pathways

Elucidate Target-Specific Pathways With a Suite of Cellular Assays

DiscoverX® offers a comprehensive collection of cell-based pathway indicator assays designed to detect activation or inhibition of complex signal transduction pathways in response to compound treatment. Based on the proven PathHunter® technology, These biosensor cell lines allow you to measure distinct events within a variety of pathways involved in compound toxicity, cholesterol metabolism, antioxidant function, DNA damage and ER stress. In combination with our biosensor cell lines with fast and simple chemiluminescent detection, DiscoverX Pathway Signaling assays will help you generate cellular pathway selectivity profiles of your compounds without relying on reporter gene assays or complex phenotypic screens.

Learn more about the updated Cell Culture and Handling Procedure in the new Technical Bulletin.

 
Therapeutic Areas

Cell Lines

Explore our growing panel of stable, target-specific, pathway indicator cell lines for assays to measure activation or inhibition of novel signaling pathways in response to compound treatment.
How pathway assays work >

Assay-Ready Kits

PathHunter® eXpress Pathway assays are complete, ready-to-use kits, including all cells and reagents to measure pathway activation or inhibition in live cells. Free yourself from lengthy cell culture and expensive instrumentation!
Learn about Assay Ready eXpress Kits >

Cell Culture Kits, Reagents & Consumables

Performance you can trust! Get the highest quality data from your cell-based pathway assays in combination with our lab-certified PathHunter® cell culture media, tissue culture reagents, and plates.

Ligands & Inhibitors

Designed to target a specific signaling pathway, our purified, reference ligands and inhibitors are a convenient and cost-effective way to validate any stable pathway cell line or assay-ready kit.
View SMKI reference compound data >
Learn about competition binding assays >

Detection Reagents

Get optimal assay performance using certified chemiluminescent or fluorescent PathHunter® Detection Reagents that have been validated for use in both 96-well and 384-well microplate formats.