Nuclear Hormone Receptors (NHRs) are ligand-activated transcription factors that, in concert with additional factors, regulate gene expression or repression and play a critical role in endocrine signaling. For discovery of novel compounds targeting NHRs, DiscoverX offers 26 cell-based assays with full-length NHR, which are ideal for measuring NHR transcriptional activation, translocation, and NHR-coactivator/corepressor interaction. Because our unique NHR assays do not require downstream transcriptional activation or lengthy 16-24 hour compound incubations characteristic of standard reporter gene assays, DiscoverX’s rapid protocols minimize cell toxicity and false positive rates, yielding results with high specificity.
Learn more about the updated Cell Culture and Handling Procedure in the new
Technical Bulletin.