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GPCR Targets

World’s Largest Portfolio, Multiple Signaling Pathways

G-protein coupled receptors (GPCRs) represent a large class of important therapeutic targets. To simplify and speed exploration of GPCR biology and drug discovery, DiscoverX offers an industry-leading portfolio of over 600 naturally coupled GPCR cell lines designed to detect GPCR signaling through second messenger activation, arrestin recruitment, and receptor internalization. Our broad collection of human and ortholog GPCR assays in a wide variety of functional readouts gives you complete flexibility to choose the ideal screening platform that meets your specific project needs. Regardless of the technology platform, DiscoverX provides the most robust, reliable, high-throughput-friendly, chemiluminescent GPCR assays available.

GPCR Reference Guide

Bile acid
Calcium sensing
Corticotropin-releasing factor
Estrogen (G protein coupled) receptor
Glycoprotein hormone receptor
Gonadotropin-releasing hormone
Kisspeptin receptor
Lysophospholipid (LPA)
Melanin-concentrating hormone
Neuromedin U
Neuropeptide B & W
Neuropeptide FF & AF
Neuropeptide S
Parathyroid hormone
Peptide P518
Platelet-activating factor
Prolactin releasing peptide receptor
Thyrotropin releasing hormone
Explore our gpcrscan Assay Panel

Cell Lines

DiscoverX offers the most comprehensive portfolio of stable, pre-validated GPCR cell lines to measure receptor signaling through second messenger, arrestin recruitment, and internalization readouts.

Assay Ready Kits

PathHunter® and cAMP Hunter™ eXpress GPCR assays are complete, ready-to-use kits that include all cells and reagents to perform functional GPCR assays in live cells. Free yourself from lengthy cell culture, expensive instrumentation, and complex assay development! Obtain robust, reliable, and high-throughput data in a chemiluminescent format.
Learn about Assay Ready kit formats >

Second Messenger Assays

Study second messenger signaling using our suite of validated biochemical assays for highly quantitative determination of cAMP, cGMP, Calcium, or IP3 accumulation.
Learn about second messenger assays >

Cell Culture Kits, Reagents & Consumables

Performance you can trust! Get the highest quality data from your cell-based GPCR assays in combination with our lab-certified PathHunter® and HitHunter® cell culture media, tissue culture reagents, and plates.

Ligands and Inhibitors

Designed to target a specific GPCR receptor or pathway, our purified reference ligands and inhibitors are a convenient and cost-effective way to validate any stable GPCR cell line or assay-ready kit.

Detection Reagents

Get optimal assay performance using certified chemiluminescent or fluorescent PathHunter® Detection Reagents that have been validated for use in both 96-well and 384-well microplate formats.