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CREB regulated transcription coactivator 1 (CRTC1)

Target Class
Pathway
Family
Transcription factor
Official Symbol
TORC1
Species
Human
Accession Number
NM_015321.1
Alias Names
CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; MECT1; TORC-1; TORC1; WAMTP1; mucoepidermoid carcinoma translocated 1; mucoepidermoid carcinoma translocated protein 1; transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein (CREB) 1; transducer of regulated cAMP response element-binding protein 1
Background
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity).
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Solution Portfolio

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Transcription factor
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Measures Background Species Cell Line
TORC1 translocation U2OS Human 93-0833C3
Assay Measures Background Species Assay Kit
TORC1 Translocation U2OS Human 93-0833E3CP19S
TORC1 Translocation U2OS Human 93-0833E3CP19M
TORC1 Translocation U2OS Human 93-0833E3CP19L

KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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