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Natriuretic peptide receptor A (NPR1)

Target Class
Pathway
Family
Guanylate Cyclase A
Official Symbol
NPR1
Species
Human
Accession Number
NM_000906.3
Alias Names
ANP-A; ANPR-A; ANPRA; ANPa; GC-A; GUC2A; GUCY2A; NPR-A; NPRA; atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor type A; atrionatriuretic peptide receptor A; guanylate cyclase A; natriuretic peptide A type receptor; natriuretic peptide receptor A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
Background
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
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Solution Portfolio

Related Group Members:

Guanylate Cyclase A
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Measures Background Species Cell Line
NPR1 Activation CHO-K1 Human 93-0804C2

KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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