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Tyrosine kinase 2 (TYK2)

Target Class
Kinase
Family
Cytosolic tyrosine kinase
Official Symbol
TYK2
Species
Human
Accession Number
NM_003331.4
Alias Names
JTK1; non-receptor tyrosine-protein kinase TYK2; tyrosine kinase 2
Background
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Cytosolic tyrosine kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0875C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0875E3CP16S
Receptor Phosphorylation U2OS Human 93-0875E3CP16M
Receptor Phosphorylation U2OS Human 93-0875E3CP16L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
  Available