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Neurotrophic tyrosine kinase receptor type 3 (NTRK3)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
TrkC
Species
Human
Accession Number
NM_001012338
Alias Names
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; NT-3 growth factor receptor; TRKC; gp145(trkC); neurotrophic tyrosine kinase, receptor, type 3; tyrosine kinase receptor C
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0464C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0464E3CP16S
Receptor Phosphorylation U2OS Human 93-0464E3CP16M
Receptor Phosphorylation U2OS Human 93-0464E3CP16L
Assay Qualified With Assay Measures Background Species Assay Kit
NT-3 SH2 Recruitment U2OS Human 93-0464Y3-00078
NT-3 SH2 Recruitment U2OS Human 93-0464Y3-00077
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available