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Neurotrophic tyrosine kinase receptor type 2 (NTRK2)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
TrkB-P75
Species
Human
Accession Number
NM_006180
Alias Names
BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; GP145-TrkB; TRKB; neurotrophic tyrosine kinase, receptor, type 2; trk-B; trkB tyrosine kinase; tropomyosin-related kinase B; tyrosine kinase receptor B
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0530C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0530E3CP16S
Receptor Phosphorylation U2OS Human 93-0530E3CP16M
Receptor Phosphorylation U2OS Human 93-0530E3CP16L
Assay Qualified With Assay Measures Background Species Assay Kit
BDNF SH2 Recruitment U2OS Human 93-0530Y3-00076
BDNF SH2 Recruitment U2OS Human 93-0530Y3-00075
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
  Available