Targets / Kinase / TEC

tec protein tyrosine kinase (TEC)

Target Class
Kinase
Family
TK
Official Symbol
TEC
Entrez Gene ID
7006
Species
Human
Accession Number
NP_003206.1
Alias Names
CD202B; TEK tyrosine kinase, endothelial; TIE-2; TIE2; VMCM; VMCM1; angiopoietin-1 receptor; endothelial tyrosine kinase; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; tunica interna endothelial cell kinase; tyrosine kinase with Ig and EGF homology domains-2; tyrosine-protein kinase receptor TEK; tyrosine-protein kinase receptor TIE-2; venous malformations, multiple cutaneous and mucosal
Background
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
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