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serum/glucocorticoid regulated kinase 1 (SGK)

Target Class
Kinase
Family
AGC
Official Symbol
SGK1
Entrez Gene ID
6446
Species
Human
Accession Number
NP_005618.2
Alias Names
SGK; serine/threonine protein kinase SGK; serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase; serum/glucocorticoid regulated kinase 1; serum/glucocorticoid-regulated kinase 1
Background
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
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Related Group Members: AGC
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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