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Rho-associated, coiled-coil containing protein kinase 1 (ROCK1)

Target Class
Kinase
Family
AGC
Official Symbol
ROCK1
Entrez Gene ID
6093
Species
Human
Accession Number
NP_005397.1
Alias Names
P160ROCK; ROCK-I; Rho kinase; Rho-associated, coiled-coil containing protein kinase 1; p160 ROCK-1; p160-ROCK; renal carcinoma antigen NY-REN-35; rho-associated protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I
Background
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008]
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Related Group Members: AGC
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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