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Platelet-derived growth factor receptor alpha (PDGFRa)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
PDGFRa
Species
Human
Accession Number
NM_006206.4
Alias Names
CD140 antigen-like family member A; CD140A; CD140a antigen; PDGF-R-alpha; PDGFR-2; PDGFR-alpha; PDGFR2; PDGFRA/BCR fusion; RHEPDGFRA; alpha-type platelet-derived growth factor receptor; platelet-derived growth factor receptor 2; platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor, alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0823C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0823E3CP16S
Receptor Phosphorylation U2OS Human 93-0823E3CP16M
Receptor Phosphorylation U2OS Human 93-0823E3CP16L
SH2 Recruitment U2OS Human 93-0823Y3-00072
SH2 Recruitment U2OS Human 93-0823Y3-00071
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available