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mitogen-activated protein kinase 14 (p38-alpha)

Target Class
Kinase
Family
CMGC
Official Symbol
MAPK14
Entrez Gene ID
1432
Species
Human
Accession Number
NP_620581.1
Alias Names
CSAID-binding protein; CSBP; CSBP1; CSBP2; CSPB1; Csaids binding protein; EXIP; MAP kinase 14; MAP kinase Mxi2; MAP kinase p38 alpha; MAX-interacting protein 2; Mxi2; PRKM14; PRKM15; RK; SAPK2A; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug-binding protein; mitogen-activated protein kinase 14; mitogen-activated protein kinase p38 alpha; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38ALPHA; p38alpha Exip; stress-activated protein kinase 2A
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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