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myosin light chain kinase (MYLK)

Target Class
Kinase
Family
CAMK
Official Symbol
MYLK
Entrez Gene ID
4638
Species
Human
Accession Number
NP_444254.3
Alias Names
AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK1; kinase-related protein; myosin light chain kinase; myosin light chain kinase, smooth muscle; myosin, light polypeptide kinase; smMLCK; smooth muscle myosin light chain kinase; telokin
Background
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: CAMK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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