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MAP/microtubule affinity-regulating kinase 1 (MARK1)

Target Class
Kinase
Family
CAMK
Official Symbol
MARK1
Entrez Gene ID
4139
Species
Human
Accession Number
NP_061120.3
Alias Names
MAP/microtubule affinity-regulating kinase 1; MARK; PAR1 homolog c; Par-1c; Par1c; serine/threonine-protein kinase MARK1
Background
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
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Solution Portfolio

Related Group Members: CAMK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available