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mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5)

Target Class
Kinase
Family
CAMK
Official Symbol
MAPKAPK5
Entrez Gene ID
8550
Species
Human
Accession Number
NP_003659.2
Alias Names
MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; PRAK; mitogen-activated protein kinase-activated protein kinase 5; p38-regulated/activated protein kinase
Background
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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Related Group Members: CAMK
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