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mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2)

Target Class
Kinase
Family
CAMK
Official Symbol
MAPKAPK2
Entrez Gene ID
9261
Species
Human
Accession Number
NP_116584.2
Alias Names
MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MK-2; MK2; mitogen-activated protein kinase-activated protein kinase 2
Background
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Related Group Members: CAMK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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