Targets / Kinase / MAK

male germ cell-associated kinase (MAK)

Target Class
Kinase
Family
CMGC
Official Symbol
MAK
Entrez Gene ID
4117
Species
Human
Accession Number
NP_005897.1
Alias Names
RP62; dJ417M14.2; male germ cell-associated kinase; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase MAK; serine/threonine-protein kinase MAK
Background
The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
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Related Group Members: CMGC
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