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large tumor suppressor kinase 1 (LATS1)

Target Class
Kinase
Family
AGC
Official Symbol
LATS1
Entrez Gene ID
9113
Species
Human
Accession Number
NP_004681.1
Alias Names
LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); WARTS; WARTS protein kinase; h-warts; large tumor suppressor homolog 1; serine/threonine-protein kinase LATS1; wts
Background
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Jul 2008]
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Related Group Members: AGC
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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