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mitogen-activated protein kinase 10 (JNK3)

Target Class
Kinase
Family
CMGC
Official Symbol
MAPK10
Entrez Gene ID
5602
Species
Human
Accession Number
NP_002744.1
Alias Names
JNK3; JNK3 alpha protein kinase; JNK3A; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; PRKM10; SAPK1b; c-Jun N-terminal kinase 3; mitogen-activated protein kinase 10; p493F12; p54bSAPK; stress activated protein kinase beta; stress-activated protein kinase 1b; stress-activated protein kinase JNK3
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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Related Group Members: CMGC
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