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mitogen-activated protein kinase 8 (JNK1)

Target Class
Kinase
Family
CMGC
Official Symbol
MAPK8
Entrez Gene ID
5599
Species
Human
Accession Number
NP_002741.1
Alias Names
JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; JUN N-terminal kinase; MAP kinase 8; PRKM8; SAPK1; SAPK1c; c-Jun N-terminal kinase 1; mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; stress-activated protein kinase 1; stress-activated protein kinase 1c
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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Related Group Members: CMGC
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