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Janus kinase 3 (JAK3(JH1domain-catalytic))

Target Class
Kinase
Family
TK
Official Symbol
JAK3
Entrez Gene ID
3718
Species
Human
Accession Number
NP_000206.2
Alias Names
JAK-3; JAK3_HUMAN; JAKL; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); L-JAK; LJAK; leukocyte Janus kinase; tyrosine-protein kinase JAK3
Background
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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