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Janus kinase 3 (JAK3)

Target Class
Kinase
Family
Cytosolic tyrosine kinase
Official Symbol
JAK3
Species
Human
Accession Number
NM_000215
Alias Names
JAK-3; JAK3_HUMAN; JAKL; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); L-JAK; LJAK; leukocyte Janus kinase; tyrosine-protein kinase JAK3
Background
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Cytosolic tyrosine kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0796C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0796E3CP16S
Receptor Phosphorylation U2OS Human 93-0796E3CP16M
Receptor Phosphorylation U2OS Human 93-0796E3CP16L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
  Available