| Biological Information | |
|---|---|
| Background Information: | Janus kinase 3 (JAK3) is a non-receptor tyrosine kinase belonging to the Janus family. It is activated by a variety of cytokine and growth factor receptors, resulting in signaling cascades that facilitate the activation of various downstream target genes. JAK3 mediates gene transcription through its well-characterized downstream signaling molecules, the signal transducers and activators of transcription proteins (STAT). Inhibition of JAK3 may impair erythropoietin (EPO)-induced erythropoiesis and protection from bain damage following hypoxia. Inhibition may also adversely effect diabetes.
GenBank AF513860 |
| Target Class: | Kinase |
| Family: | Cytosolic Tyrosine Kinase |
| Accession Number: | NM_000215.2 |
| Target Name: | JAK3 |
| Target Aliases: | JAK3, JAKL, LJAK, JAK3_HUMAN, L-JAK, JAK-3 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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JAK3, active
N-terminal 6His-tagged recombinant, human JAK3 amino acids 781-end.
Datasheets
14-629x Datasheet
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