Targets / Kinase / IRAK4

interleukin-1 receptor-associated kinase 4 (IRAK4)

Target Class
Kinase
Family
TKL
Official Symbol
IRAK4
Entrez Gene ID
51135
Species
Human
Accession Number
NP_057207.2
Alias Names
IPD1; IRAK-4; NY-REN-64; REN64; interleukin-1 receptor-associated kinase 4; renal carcinoma antigen NY-REN-64
Background
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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Related Group Members: TKL
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