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interleukin-1 receptor-associated kinase 3 (IRAK3)

Target Class
Kinase
Family
TKL
Official Symbol
IRAK3
Entrez Gene ID
11213
Species
Human
Accession Number
NP_009130.1
Alias Names
ASRT5; IL-1 receptor-associated kinase M; IRAKM; interleukin-1 receptor-associated kinase 3
Background
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
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Related Group Members: TKL
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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