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Insulin-like growth factor 1 receptor (IGF1R)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
IGF1R
Species
Human
Accession Number
NM_000875
Alias Names
CD221; IGF-I receptor; IGFIR; IGFR; JTK13; insulin-like growth factor 1 receptor; insulin-like growth factor I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation HEK 293 Human 93-0505C1
Assay Measures Background Species Assay Kit
Receptor Phosphorylation HEK 293 Human 93-0505E1CP17S
Receptor Phosphorylation HEK 293 Human 93-0505E1CP17M
Receptor Phosphorylation HEK 293 Human 93-0505E1CP17L
Assay Qualified With Assay Measures Background Species Assay Kit
IGF-1 Receptor Phosphorylation HEK 293 Human 93-0505Y1-00070
IGF-1 Receptor Phosphorylation HEK 293 Human 93-0505Y1-00069
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available