Targets / Kinase / HIPK3

homeodomain interacting protein kinase 3 (HIPK3)

Target Class
Kinase
Family
CMGC
Official Symbol
HIPK3
Entrez Gene ID
10114
Species
Human
Accession Number
NP_005725.3
Alias Names
ANPK; DYRK6; FIST; FIST3; PKY; YAK1; androgen receptor-interacting nuclear protein kinase; fas-interacting serine/threonine-protein kinase; homeodomain interacting protein kinase 3; homeodomain-interacting protein kinase 3; homolog of protein kinase YAK1
Background
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE).
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Related Group Members: CMGC
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