Targets / Kinase / GAK

cyclin G associated kinase (GAK)

Target Class
Kinase
Family
Other
Official Symbol
GAK
Entrez Gene ID
2580
Species
Human
Accession Number
NP_005246.2
Alias Names
DNAJ26; DNAJC26; auxilin-2; cyclin G associated kinase; cyclin-G-associated kinase
Background
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. [provided by RefSeq, Jul 2008]
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