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FGR proto-oncogene, Src family tyrosine kinase (FGR)

Target Class
Kinase
Family
Cytosolic tyrosine kinase
Official Symbol
FGR
Species
Human
Accession Number
NM_005248.2
Alias Names
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; SRC2; c-fgr; c-fgr protooncogene; c-src-2 proto-oncogene; c-src2; p55-Fgr; p55-c-fgr protein; p55c-fgr; p58-Fgr; p58c-fgr; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; tyrosine-protein kinase Fgr
Background
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Cytosolic tyrosine kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0884C3
Intracellular Binding HEK 293 96-0043C1
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0884E3CP16S
Receptor Phosphorylation U2OS Human 93-0884E3CP16M
Receptor Phosphorylation U2OS Human 93-0884E3CP16L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available