Find a Product

fibroblast growth factor receptor 4 (FGFR4)

Target Class
Kinase
Family
TK
Official Symbol
FGFR4
Entrez Gene ID
2264
Species
Human
Accession Number
NP_075252.2
Alias Names
CD334; FGFR-4; JTK2; TKF; fibroblast growth factor receptor 4; hydroxyaryl-protein kinase; protein-tyrosine kinase; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase
Background
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
+ Show More


Solution Portfolio

Related Group Members: TK
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-1022C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-1022E3CP16S
Receptor Phosphorylation U2OS Human 93-1022E3CP16M
Receptor Phosphorylation U2OS Human 93-1022E3CP16L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available