Find a Product

Fibroblast growth factor receptor 1 (FGFR1)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
FGFR1
Species
Human
Accession Number
NM_001174063
Alias Names
BFGFR; CD331; CEK; FGFBR; FGFR-1; FGFR1/PLAG1 fusion; FLG; FLT-2; FLT2; FMS-like tyrosine kinase 2; HBGFR; KAL2; N-SAM; OGD; bFGF-R-1; basic fibroblast growth factor receptor 1; fibroblast growth factor receptor 1; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; proto-oncogene c-Fgr
Background
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
+ Show More


Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-1090C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0850E3CP16S
Receptor Phosphorylation U2OS Human 93-0850E3CP16M
Receptor Phosphorylation U2OS Human 93-0850E3CP16L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available