Targets / Kinase / ERN1

endoplasmic reticulum to nucleus signaling 1 (ERN1)

Target Class
Kinase
Family
Other
Official Symbol
ERN1
Entrez Gene ID
2081
Species
Human
Accession Number
NP_001424.3
Alias Names
ER to nucleus signalling 1; IRE1; IRE1P; IRE1a; endoplasmic reticulum to nucleus signaling 1; endoplasmic reticulum-to-nucleus signaling 1; hIRE1p; inositol-requiring 1; inositol-requiring enzyme 1; inositol-requiring protein 1; ire1-alpha; protein kinase/endoribonuclease; serine/threonine-protein kinase/endoribonuclease IRE1
Background
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]
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