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mitogen-activated protein kinase 7 (ERK5)

Target Class
Kinase
Family
CMGC
Official Symbol
MAPK7
Entrez Gene ID
5598
Species
Human
Accession Number
NP_002740.2
Alias Names
BMK-1; BMK1; BMK1 kinase; ERK-5; ERK4; ERK5; MAP kinase 7; MAPK 7; PRKM7; big MAP kinase 1; extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5; mitogen-activated protein kinase 7
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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Related Group Members: CMGC
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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