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erb-b2 receptor tyrosine kinase 2 (ERBB2)

Target Class
Kinase
Family
TK
Official Symbol
ERBB2
Entrez Gene ID
2064
Species
Human
Accession Number
NP_001005862.1
Alias Names
CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1; c-erb B2/neu protein; herstatin; metastatic lymph node gene 19 protein; neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; proto-oncogene Neu; proto-oncogene c-ErbB-2; receptor tyrosine-protein kinase erbB-2; tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Background
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: TK
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
ErbB2/ErbB4 Dimerization U2OS Human 93-0960C3
EGFR/ErbB2 Dimerization U2OS Human 93-1051C3
ErbB2/ErbB3 Dimerization U2OS Human 93-1042C3
Assay Measures Background Species Assay Kit
ErbB2/ErbB4 Dimerization U2OS Human 93-0960E3CP5S
ErbB2/ErbB4 Dimerization U2OS Human 93-0960E3CP5M
ErbB2/ErbB4 Dimerization U2OS Human 93-0960E3CP5L
EGFR/ErbB2 Dimerization U2OS Human 93-1051E3CP14S
EGFR/ErbB2 Dimerization U2OS Human 93-1051E3CP14M
EGFR/ErbB2 Dimerization U2OS Human 93-1051E3CP14L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available