Targets / Kinase / EIF2AK1

eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)

Target Class
Kinase
Family
Other
Official Symbol
EIF2AK1
Entrez Gene ID
27102
Species
Human
Accession Number
NP_055228.2
Alias Names
HCR; HRI; eukaryotic translation initiation factor 2-alpha kinase 1; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; heme-controlled repressor; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; heme-regulated initiation factor 2-alpha kinase; heme-regulated repressor; hemin-sensitive initiation factor 2-alpha kinase
Background
The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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