Targets / Kinase / EGFR(G719C)

epidermal growth factor receptor (EGFR(G719C))

Target Class
Kinase
Family
TK
Official Symbol
EGFR
Entrez Gene ID
1956
Species
Human
Accession Number
NP_005219.2
Alias Names
ERBB; ERBB1; HER1; PIG61; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog); mENA; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1
Background
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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