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doublecortin-like kinase 1 (DCAMKL1)

Target Class
Kinase
Family
CAMK
Official Symbol
DCLK1
Entrez Gene ID
9201
Species
Human
Accession Number
NP_004725.1
Alias Names
CL1; CLICK1; DCAMKL1; DCDC3A; DCLK; doublecortin and CaM kinase-like 1; doublecortin domain-containing protein 3A; doublecortin-like and CAM kinase-like 1; doublecortin-like kinase 1; serine/threonine-protein kinase DCLK1
Background
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
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Related Group Members: CAMK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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