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megakaryocyte-associated tyrosine kinase (CTK)

Target Class
Kinase
Family
TK
Official Symbol
MATK
Entrez Gene ID
4145
Species
Human
Accession Number
NP_002369.2
Alias Names
CHK; CSK homologous kinase; CTK; Csk-homologous kinase; Csk-type protein tyrosine kinase; HHYLTK; HYL; HYL tyrosine kinase; HYLTK; Lsk; hematopoietic consensus tyrosine-lacking kinase; hydroxyaryl-protein kinase; leukocyte carboxyl-terminal src kinase related; megakaryocyte-associated tyrosine kinase; megakaryocyte-associated tyrosine-protein kinase; protein kinase HYL; tyrosine kinase MATK; tyrosine-protein kinase CTK; tyrosylprotein kinase
Background
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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