Targets / Kinase / CSNK1G2

casein kinase 1, gamma 2 (CSNK1G2)

Target Class
Kinase
Family
CK1
Official Symbol
CSNK1G2
Entrez Gene ID
1455
Species
Human
Accession Number
NP_001310.2
Alias Names
CK1g2; CKI-gamma 2; casein kinase 1 isoform gamma-2; casein kinase 1, gamma 2; casein kinase I isoform gamma-2
Background
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.
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Related Group Members: CK1
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