Find a Product

casein kinase 1, gamma 2 (CSNK1G2)

Target Class
Kinase
Family
CK1
Official Symbol
CSNK1G2
Entrez Gene ID
1455
Species
Human
Accession Number
NP_001310.2
Alias Names
CK1g2; CKI-gamma 2; casein kinase 1 isoform gamma-2; casein kinase 1, gamma 2; casein kinase I isoform gamma-2
Background
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.
+ Show More


Solution Portfolio

Related Group Members: CK1
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available